Heparan sulfate regulates amphiregulin programming of tissue reparative lung mesenchymal cells during influenza A virus infection in mice

Abstract Amphiregulin (Areg), a growth factor produced by regulatory T (Treg) cells to facilitate tissue repair, contains a heparan sulfate (HS) binding domain. How HS, a highly sulfated glycan subtype that alters growth factor signaling, influences Areg repair functions is unclear. Here we report t...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Lucas F. Loffredo, Anmol Kustagi, Olivia R. Ringham, Fangda Li, Kenia de los Santos-Alexis, Anjali Saqi, Nicholas Arpaia
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-03-01
Online Access:	https://doi.org/10.1038/s41467-025-57362-z