Continual Deletion of Spinal Microglia Reforms Astrocyte Scar Favoring Axonal Regeneration

Astrocyte scar formation after spinal cord injury (SCI) efficiently limits the accurate damage but physically restricts the following axon regeneration. Lately, fine tuning scar formation is becoming a novel strategy to develop SCI treatment, yet how to leverage these opposite effects remains challe...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Longkuo Xia, Jianhuan Qi, Mingming Tang, Jing Liu, Da Zhang, Yanbing Zhu, Baoyang Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Subjects:	astrocyte scar microglia spinal cord injury scar-formed astrocyte collagen I
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.881195/full