In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation

Abstract One of the main hallmarks of Parkinson’s disease (PD) is abnormal alpha-synuclein (α-syn) aggregation which forms the main component of intracellular Lewy body inclusions. This short report used preformed α-syn fibrils, as well as an A53T mutant α-syn adenovirus to mimic conditions of patho...

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Bibliographic Details

Published in:	Molecular Brain
Main Authors:	Viktoria Xing, Kyle Biggar, Stephen S. G. Ferguson, Shawn Hayley
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	α-synuclein mGluR5 Parkinson’s disease mTOR In vitro
Online Access:	https://doi.org/10.1186/s13041-023-01074-2