Plasminogen Activator Inhibitor-1 in Skin Malignancies: Therapeutic Implications of Its Inhibition

Plasminogen activator inhibitor-1 (PAI-1), a key regulator of fibrinolysis, has emerged as a critical stromal factor that contributes to tumor progression in various malignancies, including skin cancers. Beyond its classical role in inhibiting plasminogen activators, PAI-1 exerts pleiotropic effects...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Taku Fujimura, Yusuke Muto, Yoshihide Asano
Format:	Article
Language:	English
Published:	MDPI AG 2025-09-01
Subjects:	PAI-1 tumor microenvironment SASP melanoma immune checkpoints angiogenesis
Online Access:	https://www.mdpi.com/2218-273X/15/9/1317