Pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS

IntroductionMRTX1133 is a selective and reversible small molecule inhibitor of KRAS (G12D), which significantly delays the progression of solid tumors. However, no study on the absorption, distribution, and excretion of MRTX1133.MethodsA fast ultra-high performance liquid chromatography-tandem quadr...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Wei Lu, Rong Zeng, Meng Pan, Yuan Zhou, Huijuan Tang, Wanying Shen, Yijun Tang, Pan Lei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Subjects:	MRTX1133 UHPLC-MS/MS pharmacokinetics distribution excretion
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1509319/full