Heterogeneity of treatment effect of interferon-β1b and lopinavir–ritonavir in patients with Middle East respiratory syndrome by cytokine levels

Abstract Animal and human data indicate variable effects of interferons in treating coronavirus infections according to inflammatory status and timing of therapy. In this sub-study of the MIRACLE trial (MERS-CoV Infection Treated with a Combination of Lopinavir–Ritonavir and Interferon β-1b), we eva...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Yaseen M. Arabi, Ayed Y. Asiri, Abdullah M. Assiri, Mashan L. Abdullah, Haya A. Aljami, Hanan H. Balkhy, Majed Al Jeraisy, Yasser Mandourah, Sameera AlJohani, Shmeylan Al Harbi, Hani A. Aziz Jokhdar, Ahmad M. Deeb, Ziad A. Memish, Jesna Jose, Sameeh Ghazal, Sarah Al Faraj, Ghaleb A. Al Mekhlafi, Nisreen Murad Sherbeeni, Fatehi Elnour Elzein, Frederick G. Hayden, Robert A. Fowler, Badriah M. AlMutairi, Abdulaziz Al-Dawood, Naif Khalaf Alharbi
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-10-01
Online Access:	https://doi.org/10.1038/s41598-022-22742-8