Synthesis, characterization, cytotoxic screening, and density functional theory studies of new derivatives of quinazolin-4(3H)-one Schiff bases

A series of novel derivatives of quinazolinone Schiff bases were synthesized from benzoic acid starting material and evaluated for potential cytotoxic activities against the human breast adenocarcinoma (MCF-7) and the human colon adenocarcinoma (HT-29) cell lines. Compared to the reference drug, the...

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Bibliographic Details

Published in:	Research in Pharmaceutical Sciences
Main Authors:	Rezvan Rezaee Nasab, Farshid Hassanzadeh, Ghadam Ali Khodarahmi, Mahmoud Mirzaei, Mahboubeh Rostami, Ali Jahanian-Najaf abadi
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2017-01-01
Subjects:	quinazolinone; schiff base; density functional theory; cytotoxic activity; quantitative structure-activity relationship
Online Access:	http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2017;volume=12;issue=6;spage=444;epage=455;aulast=Nasab