Ghost protein damage by peroxynitrite and its protection by melatonin

We have studied the effect of peroxynitrite (ONOO-) on the membrane cytoskeleton of red blood cells and its protection by melatonin. Analysis of the protein fraction of the preparation by SDS-PAGE revealed a dose-dependent (0-600 µM ONOO-) disappearance at pH 7.4 of the main proteins: spectrin, band...

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Bibliographic Details

Published in:	Brazilian Journal of Medical and Biological Research
Main Authors:	P. Di Mascio, B. Dewez, C.R.S. Garcia
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2000-01-01
Subjects:	peroxynitrite melatonin spectrin protein ghost thiols
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100002