The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy

Erythropoietin (EPO), a hematopoietic neurotrophin, is a potential therapeutic for Alzheimer’s disease (AD) but has limited blood–brain barrier (BBB) permeability. EPO fused to a chimeric transferrin receptor monoclonal antibody (cTfRMAb) enters the brain via TfR-mediated transcytosis across the BBB...

Full description

Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Joshua Yang, Weijun Ou, Nataraj Jagadeesan, Juste Simanauskaite, Jiahong Sun, Demi Castellanos, David H. Cribbs, Rachita K. Sumbria
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	Alzheimer’s disease blood–brain barrier erythropoietin microglia molecular Trojan horse monoclonal antibody
Online Access:	https://www.mdpi.com/1424-8247/16/4/558