Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components

miRNAs constitute fine-tuners of gene expression and are implicated in a variety of diseases spanning from inflammation to cancer. miRNA expression is deregulated in rheumatoid arthritis (RA); however, their specific role in key arthritogenic cells such as the synovial fibroblast (SF) remains elusiv...

Full description

Bibliographic Details

Published in:	eLife
Main Authors:	Fani Roumelioti, Christos Tzaferis, Dimitris Konstantopoulos, Dimitra Papadopoulou, Alejandro Prados, Maria Sakkou, Anastasios Liakos, Panagiotis Chouvardas, Theodore Meletakos, Yiannis Pandis, Niki Karagianni, Maria C Denis, Maria Fousteri, Maria Armaka, George Kollias
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-09-01
Subjects:	miRNAs rheumatoid arthritis synovial fibroblasts expansion cell proliferation sc-ATAC seq
Online Access:	https://elifesciences.org/articles/84698