Substituted 1,4-naphthoquinones for potential anticancer therapeutics: In vitro cytotoxic effects and QSAR-guided design of new analogs

1,4-Naphthoquinone is a promising pharmacophore in drug discovery due to its unique redox reactive nature and wide-ranging bioactivities. Herein, a series of 1,4-naphthoquinones (1-14) were investigated for their anticancer activities against 4 cancer cell lines (i.e., HepG2, HuCCA-1, A549, and MOLT...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Veda Prachayasittikul, Prasit Mandi, Ratchanok Pingaew, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Naphthoquinone Anticancer QSAR ADMET Computer-aided drug design
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037025003046