Functional assessment of the NMDA receptor variant GluN2AR586K [version 1; referees: 1 approved, 2 approved with reservations]

Background: The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor that has important roles in synaptogenesis, synaptic transmission, and synaptic plasticity. Recently, a large number of rare genetic variants have been found in NMDAR subunits in people with neurodevelopmental...

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Bibliographic Details

Published in:	Wellcome Open Research
Main Authors:	Katie F.M. Marwick, Peter Parker, Paul Skehel, Giles Hardingham, David J.A. Wyllie
Format:	Article
Language:	English
Published:	Wellcome 2017-03-01
Subjects:	Developmental & Pediatric Neurology Medical Genetics
Online Access:	https://wellcomeopenresearch.org/articles/2-20/v1