Mutant Huntingtin Forms in Vivo Complexes with Distinct Context-Dependent Conformations of the Polyglutamine Segment

Huntington's disease (HD) is caused by an expanded glutamine tract, which confers a novel aggregation-promoting property on the 350-kDa huntingtin protein. Using specific antibodies, we have probed the structure of the polyglutamine segment in mutant huntingtin complexes formed in cell culture...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Francesca Persichetti, Flavia Trettel, C.Chris Huang, Cornel Fraefel, H.T.Marc Timmers, James F. Gusella, Marcy E. MacDonald
Format:	Article
Language:	English
Published:	Elsevier 1999-10-01
Subjects:	Huntington's disease huntingtin aggregation polyglutamine 1F8 mAb.
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996199902607