Di-PEGylated insulin: A long-acting insulin conjugate with superior safety in reducing hypoglycemic events

Although the discovery of insulin 100 years ago revolutionized the treatment of diabetes, its therapeutic potential is compromised by its short half-life and narrow therapeutic index. Current long-acting insulin analogs, such as insulin-polymer conjugates, are mainly used to improve pharmacokinetics...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Zhipeng Zeng, Runcheng Tan, Shi Chen, Haolin Chen, Zhijia Liu, Lixin Liu, Mingqiang Li, Yongming Chen
Format:	Article
Language:	English
Published:	Elsevier 2024-06-01
Subjects:	Diabetes Insulin Therapeutic index Hypoglycemia PEGylation Receptor-mediated clearance
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383524000753