Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers with very few available treatments. For many decades, gemcitabine was the only treatment for patients with PDAC. A recent attempt to improve patient survival by combining this chemotherapy with FOLFIRINOX and na...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Etienne D. Foucher, Clément Ghigo, Salem Chouaib, Jérôme Galon, Juan Iovanna, Daniel Olive
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Subjects:	pancreatic ductal adenocarcinoma immune infiltrate tumor microenvironment immunosuppression hypoxia immune checkpoint
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.01044/full