Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal cancers with very few available treatments. For many decades, gemcitabine was the only treatment for patients with PDAC. A recent attempt to improve patient survival by combining this chemotherapy with FOLFIRINOX and na...

書誌詳細
出版年:	Frontiers in Immunology
主要な著者:	Etienne D. Foucher, Clément Ghigo, Salem Chouaib, Jérôme Galon, Juan Iovanna, Daniel Olive
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2018-05-01
主題:	pancreatic ductal adenocarcinoma immune infiltrate tumor microenvironment immunosuppression hypoxia immune checkpoint
オンライン･アクセス:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.01044/full

類似資料

Unveiling the immunosuppressive landscape of pancreatic ductal adenocarcinoma: implications for innovative immunotherapy strategies
著者:: Songyu Guo, 等
出版事項: (2024-03-01)

Immunohistochemical Evaluation of the Tumor Immune Microenvironment in Pancreatic Ductal Adenocarcinoma
著者:: Gelu Mihai Breaza, 等
出版事項: (2025-03-01)

Comparative immune profiling of pancreatic ductal adenocarcinoma progression among South African patients
著者:: Nnenna Elebo, 等
出版事項: (2024-07-01)

Immune Landscape of Invasive Ductal Carcinoma Tumor Microenvironment Identifies a Prognostic and Immunotherapeutically Relevant Gene Signature
著者:: Xuanwen Bao, 等
出版事項: (2019-09-01)

Decoding tumor-infiltrating lymphocytes heterogeneity in ductal carcinoma in situ: immune microenvironment dynamics and prognostic insights
著者:: Lingzi Wang, 等
出版事項: (2025-07-01)

The immunoregulation effect of tumor microenvironment in pancreatic ductal adenocarcinoma
著者:: Jingchang Zhang, 等
出版事項: (2022-07-01)

BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC)
著者:: Audrey Benyamine, 等
出版事項: (2018-01-01)

Intratumoral microbiota of pancreatic ductal adenocarcinoma impact patient prognosis by influencing tumor microenvironment
著者:: Jingze Leng, 等
出版事項: (2024-09-01)

Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts
著者:: Linda Ziani, 等
出版事項: (2018-03-01)

Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment
著者:: Xiuyun Jiang, 等
出版事項: (2017-07-01)

Abnormalities in T cell subsets in the circulating immunity and tumor microenvironment in patients with pancreatic ductal adenocarcinoma
著者:: SU Bingwei, SHEN Baiyong
出版事項: (2025-03-01)

The immune escape signature predicts the prognosis and immunotherapy sensitivity for pancreatic ductal adenocarcinoma
著者:: Hao Lu, 等
出版事項: (2022-09-01)

Good Cop, Bad Cop: Profiling the Immune Landscape in Multiple Myeloma
著者:: Niyati Seshagiri Sharma, 等
出版事項: (2023-11-01)

Metabolic syndrome related gene signature predicts the prognosis of patients with pancreatic ductal carcinoma. A novel link between metabolic dysregulation and pancreatic ductal carcinoma
著者:: Weiyang Cai, 等
出版事項: (2021-12-01)

Perineural invasion and the “cold” tumor microenvironment in pancreatic cancer: mechanisms of crosstalk and therapeutic opportunities
著者:: Jianbiao Xu, 等
出版事項: (2025-08-01)

Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3
著者:: Rosalinda Trovato, 等
出版事項: (2019-09-01)

Characterization of 3D heterocellular spheroids of pancreatic ductal adenocarcinoma for the study of cell interactions in the tumor immune microenvironment
著者:: Giulio Giustarini, 等
出版事項: (2023-07-01)

Unveiling the immunological terrain of pancreatic ductal adenocarcinoma: strategies to prompt immunotherapy from Mendelian randomization
著者:: Peizan Ni, 等
出版事項: (2025-04-01)

Investigating the correlation between tertiary lymphoid structures and clinical outcomes in pancreatic ductal adenocarcinoma: insights into tumor immunology
著者:: Lingbo Hu, 等
出版事項: (2025-06-01)

Single-cell transcriptome reveals the heterogeneity of malignant ductal cells and the prognostic value of REG4 and SPINK1 in primary pancreatic ductal adenocarcinoma
著者:: Yutian Ji, 等
出版事項: (2024-05-01)

Identification of an Immune-Related Signature for Predicting Prognosis in Patients With Pancreatic Ductal Adenocarcinoma
著者:: Weijia Wang, 等
出版事項: (2021-02-01)

Deciphering the secrets of tumor-initiating cells in pancreatic ductal adenocarcinoma microenvironment: mechanisms and therapeutic opportunities
著者:: Jun Zhou, 等
出版事項: (2025-08-01)

Immunological Classification of Pancreatic Carcinomas to Identify Immune Index and Provide a Strategy for Patient Stratification
著者:: Yi Chen, 等
出版事項: (2022-01-01)

Hydrogel-Based Therapeutics for Pancreatic Ductal Adenocarcinoma Treatment
著者:: Jinlu Liu, 等
出版事項: (2023-10-01)

Editorial: Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy
著者:: Salem Chouaib, 等
出版事項: (2020-05-01)

Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines
著者:: Klasse Per, 等
出版事項: (2012-10-01)

Effects of NK cell-related lncRNA on the immune microenvironment and molecular subtyping for pancreatic ductal adenocarcinoma
著者:: Jinze Li, 等
出版事項: (2025-01-01)

Immunocytes in the tumor microenvironment: recent updates and interconnections
著者:: Jiyao Yu, 等
出版事項: (2025-04-01)

Stuttering as a signal of encephalopathy associated with toripalimab in a pancreatic ductal adenocarcinoma patient: a case report
著者:: Jianping He, 等
出版事項: (2023-03-01)

Lactate-related lncRNAs assessment model predicts the prognosis of pancreatic ductal adenocarcinoma
著者:: Jing Sun, 等
出版事項: (2025-07-01)

Tumor-Infiltrating Immune Cell Signature Predicts the Prognosis and Chemosensitivity of Patients With Pancreatic Ductal Adenocarcinoma
著者:: Yuzhen Gao, 等
出版事項: (2020-09-01)

Updates on Measles Incidence and Eradication: Emphasis on the Immunological Aspects of Measles Infection
著者:: Ali A. Rabaan, 等
出版事項: (2022-05-01)

Establishment and validation of a prognostic signature for pancreatic ductal adenocarcinoma based on lactate metabolism-related genes
著者:: Xin Huang, 等
出版事項: (2023-06-01)

Research progress of the immunosuppressive tumor microenvironment in multiple myeloma
著者:: Yue WANG, 等
出版事項: (2025-08-01)

The tumor immune microenvironment: implications for cancer immunotherapy, treatment strategies, and monitoring approaches
著者:: Kelsey Jane Racacho, 等
出版事項: (2025-09-01)

CCL2 produced by pancreatic ductal adenocarcinoma is essential for the accumulation and activation of monocytic myeloid‐derived suppressor cells
著者:: Haitao Gu, 等
出版事項: (2021-12-01)

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges
著者:: Muhammad Zaeem Noman, 等
出版事項: (2019-09-01)

Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma
著者:: Farrukh Afaq, 等
出版事項: (2024-01-01)

Advances in the imbalance of the immune microenvironment in the chronically photodamaged skin
著者:: Xinling CHEN, 等
出版事項: (2023-12-01)

Clinical and immunological efficacy of combination therapy of children with measles
著者:: V. N. Timchenko, 等
出版事項: (2016-11-01)