Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson’s disease: implication of acrolein and TRPA1

Abstract Background The mechanisms underlying lesions of dopaminergic (DA) neurons, an essential pathology of Parkinson’s disease (PD), are largely unknown, although oxidative stress is recognized as a key factor. We have previously shown that the pro-oxidative aldehyde acrolein is a critical factor...

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Bibliographic Details

Published in:	Translational Neurodegeneration
Main Authors:	Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A. Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen, Riyi Shi
Format:	Article
Language:	English
Published:	BMC 2021-04-01
Subjects:	Oxidative stress Parkinson’s disease Neuroinflammation Acrolein TRPA1 Dimercaprol
Online Access:	https://doi.org/10.1186/s40035-021-00239-0