Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8⁺ T Cells

During acute infections, CD8⁺ T cells form various memory subpopulations to provide long-lasting protection against reinfection. T central memory (TCM), T effector memory (TEM), and long-lived effector (LLE) cells are circulating memory populations with distinct plasticity, mi...

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Bibliographic Details

Published in:	Cells
Main Authors:	Yao Chen, Jian Shen, Moujtaba Y. Kasmani, Paytsar Topchyan, Weiguo Cui
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	CD8 tissue-resident memory T cell LCMV infection single-cell RNA-sequencing heterogeneity transcriptional regulation transcription factors
Online Access:	https://www.mdpi.com/2073-4409/10/8/2143