The importance of microtubule-dependent tension in accurate chromosome segregation

Accurate chromosome segregation is vital for cell and organismal viability. The mitotic spindle, a bipolar macromolecular machine composed largely of dynamic microtubules, is responsible for chromosome segregation during each cell replication cycle. Prior to anaphase, a bipolar metaphase spindle mus...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Angela R. Bunning, Mohan L. Gupta Jr.
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Subjects:	spindle checkpoint tension chromosome segregation microtubule kinetochore
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1096333/full