Impact of aging on CD146+ mesenchymal stromal cells-mediated regulation of bone marrow CD34+ hematopoietic stem/progenitor cell mobilization

BackgroundThe study of age-associated changes in the bone marrow (BM), a key organ for hematopoiesis and immune regulation, is crucial to understanding inflammatory processes linked to cardiovascular diseases. Notably, aging is associated with impaired mobilization of BM-derived cardioprotective CD3...

Full description

Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Marzia Campanile, Miruna Larisa Naie, Milena Bertolotti, Ivan Muradore, Chiara Riccardi, Andrea Rampin, Giuseppe Noto, Paolo Angelo Laviano, Viola Melone, Domenico Palumbo, Roberta Tarallo, Alessandro Fantin, Elena Butoi, Gaia Spinetti
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2026-05-01
Subjects:	aging bone marrow hematopoietic stem/progenitor cells In vitro models migration stromal cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2026.1802093/full