Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei

Abstract Background Given the global rise in antimicrobial resistance, the discovery of novel antimicrobial agents and production processes thereof are of utmost importance. To this end we have activated the gene cluster encoding for the biosynthesis of the potent antifungal compound ilicicolin H in...

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Bibliographic Details

Published in:	Biotechnology for Biofuels and Bioproducts
Main Authors:	Isabella Burger, Matthias Schmal, Kathrin Peikert, Lukas Fourtis, Christoph Suster, Christian Stanetty, Dominik Schnalzer, Barbara Hufnagel, Thomas Böttcher, Ruth Birner-Gruenberger, Robert L. Mach, Astrid R. Mach-Aigner, Matthias Schittmayer, Christian Zimmermann
Format:	Article
Language:	English
Published:	BMC 2025-03-01
Subjects:	Natural products Multi-omics Fungi Antifungal agents Pathway engineering
Online Access:	https://doi.org/10.1186/s13068-025-02628-3