Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

Eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that exist at the kilo-megabase scale. Here Cattoni et al. combine super-resolution microscopy with DNA-labeling methods to quantify absolute frequencies of interactions within TADs.

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Diego I. Cattoni, Andrés M. Cardozo Gizzi, Mariya Georgieva, Marco Di Stefano, Alessandro Valeri, Delphine Chamousset, Christophe Houbron, Stephanie Déjardin, Jean-Bernard Fiche, Inma González, Jia-Ming Chang, Thomas Sexton, Marc A. Marti-Renom, Frédéric Bantignies, Giacomo Cavalli, Marcelo Nollmann
Format:	Article
Language:	English
Published:	Nature Portfolio 2017-11-01
Online Access:	https://doi.org/10.1038/s41467-017-01962-x