Glucocorticoid Receptor Antagonism Upregulates Somatostatin Receptor Subtype 2 Expression in ACTH-Producing Neuroendocrine Tumors: New Insight Based on the Selective Glucocorticoid Receptor Modulator Relacorilant

Somatostatin exhibits an inhibitory effect on pituitary hormone secretion, including inhibition of growth hormone and adrenocorticotropic hormone (ACTH), and it can have antisecretory and antitumor effects on neuroendocrine tumors (NETs) that express somatostatin receptors. Although the precise mech...

Full description

Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Rosario Pivonello, Pamela N. Munster, Massimo Terzolo, Rosario Ferrigno, Chiara Simeoli, Soraya Puglisi, Utsav Bali, Andreas G. Moraitis
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	glucocorticoid cortisol somatostatin relacorilant neuroendocrine tumor adrenocorticotropic hormone
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2021.793262/full