Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter- and intra-cellular communication, which regulates fundamental cell functions such as growth, survival, and differentiation. The MAPK pathway also integrates signals from complex intracellular networks in performing cellular fu...

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Bibliographic Details

Published in:	Cells
Main Authors:	Ufuk Degirmenci, Mei Wang, Jiancheng Hu
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Subjects:	ras gtpases raf family kinases ras/raf/mek/erk signaling braf(v600e) raf inhibitors paradoxical activation protein–protein interactions synthetic lethal neoplasm
Online Access:	https://www.mdpi.com/2073-4409/9/1/198