Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent manner

The newly emerged severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) can result in dysregulated interferon (IFN) responses that contribute to disease severity. The papain-like protease of SARS-CoV-2 (SCoV2-PLpro) has been previously reported to attenuate IFN responses, but the under...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Xiang-Hong Ran, Jia-Wu Zhu, Ya-Yun Chen, Run-Ze Ni, Dan Mu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	SARS-CoV-2 papain-like protease RLR signaling IFN deubiquitination
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.947272/full