Revisiting the alpha-synuclein paradox in melanoma-Parkinson’s disease connection: more than a tale of two cell fates

Abstract Since the first report in 1972, several studies have documented an association between Parkinson’s disease (PD) and melanoma. Up to 20-fold increased risk of melanoma was reported in PD patients, while a personal/family history of melanoma was linked to a 1.85-fold PD risk. Neurons and mela...

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Bibliographic Details
Published in:Cellular and Molecular Life Sciences
Main Authors: Jacopo Aiello, Roberta Zamarato, Claudia Moscheni, Cristiana Perrotta, Mario Clerici, Daria Trabattoni, Mara Biasin, Fiona Limanaqi
Format: Article
Language:English
Published: Springer 2025-12-01
Subjects:
Neurodegeneration
Cancer
Dopamine
Iron
(Neuro)melanin
Oxidative stress
Online Access:https://doi.org/10.1007/s00018-025-05985-2

Internet

https://doi.org/10.1007/s00018-025-05985-2

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