Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism

Infecting humans with controlled doses of helminths, such as human hookworm (termed hookworm therapy), is proposed to prevent or treat various intestinal and extraintestinal diseases. However, full-scale clinical trials examining hookworm therapy are limited by the inability to scale-up the producti...

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Bibliographic Details

Published in:	Gut Microbes
Main Authors:	Francesco Vacca, Thomas C. Mules, Mali Camberis, Brittany Lavender, Sophia-Louise Noble, Alissa Cait, Kate Maclean, John Mamum, Bibek Yumnam, Tama Te Kawa, Laura Ferrer-Font, Jeffry S. Tang, Olivier Gasser, Graham Le Gros, Stephen Inns
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2024-12-01
Subjects:	Hookworm helminths microbiome immune regulation eosinophilia clinical trial
Online Access:	https://www.tandfonline.com/doi/10.1080/19490976.2024.2416517