Peroxisomal defects in microglial cells induce a disease-associated microglial signature

Microglial cells ensure essential roles in brain homeostasis. In pathological condition, microglia adopt a common signature, called disease-associated microglial (DAM) signature, characterized by the loss of homeostatic genes and the induction of disease-associated genes. In X-linked adrenoleukodyst...

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Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Quentin Raas, Ali Tawbeh, Mounia Tahri-Joutey, Catherine Gondcaille, Céline Keime, Romain Kaiser, Doriane Trompier, Boubker Nasser, Valerio Leoni, Emma Bellanger, Maud Boussand, Yannick Hamon, Alexandre Benani, Francesca Di Cara, Caroline Truntzer, Mustapha Cherkaoui-Malki, Pierre Andreoletti, Stéphane Savary
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	peroxisome adrenoleukodystrophy (X-ALD) microglia lysosome lipid metabolism autophagy
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1170313/full