PopPK modeling supports BW band dosing of lacosamide for pediatric epilepsy

Abstract Personalized precision dosing remains an unmet clinical need. This study used population pharmacokinetic (PopPK) modeling to evaluate transitioning lacosamide (LCM) in children with epilepsy from body weight (BW)-based (mg/kg) to simplified BW-band or fixed-dose (mg) regimens. Real-world da...

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Bibliographic Details

Published in:	npj Genomic Medicine
Main Authors:	Yue Li, Hong-Li Guo, Lin Fan, Jie Wang, Ya-Hui Hu, Yuan-Yuan Zhang, Jin-Chun Qiu, Jing Chen, Chun-Feng Wu, Gang Zhang, Xiao-Peng Lu, Feng Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Online Access:	https://doi.org/10.1038/s41525-025-00519-y