Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates

Abstract Background The lack of a universal influenza vaccine is a global health problem. Interest is now focused on structurally conserved protein domains capable of eliciting protection against a broad range of influenza virus strains. The long alpha helix (LAH) is an attractive vaccine component...

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Bibliographic Details

Published in:	BMC Biotechnology
Main Authors:	Andris Kazaks, I-Na Lu, Sophie Farinelle, Alex Ramirez, Vincenzo Crescente, Benjamin Blaha, Olotu Ogonah, Tarit Mukhopadhyay, Mapi Perez de Obanos, Alejandro Krimer, Inara Akopjana, Janis Bogans, Velta Ose, Anna Kirsteina, Tatjana Kazaka, Nicola J. Stonehouse, David J. Rowlands, Claude P. Muller, Kaspars Tars, William M. Rosenberg
Format:	Article
Language:	English
Published:	BMC 2017-11-01
Subjects:	Virus-like particles Tandem-core Influenza vaccine Long alpha helix Yeast
Online Access:	http://link.springer.com/article/10.1186/s12896-017-0396-8