Levels of neuroactive steroids are elevated in those who develop first-onset depression early in pregnancy

BackgroundAllopregnanolone (ALLO) plays a key role in the pathogenesis of postpartum depression. However, ALLO levels have been variably associated with depression during pregnancy. It is unknown if a pre-pregnancy history of major depressive disorder (MDD), which is associated with blunted neuroste...

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Bibliographic Details

Published in:	Frontiers in Psychiatry
Main Authors:	Elizabeth S. Wenzel, Jordan C. Barone, Tory A. Eisenlohr-Moul, Suzanne Alvernaz, Beatriz Peñalver Bernabé, Luca Spiro Santovito, Ibrahim M. M. Gdyana, Graziano Pinna, Pauline M. Maki
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	neuroactive steroids perinatal depression allopregnanolone antenatal depression pregnancy
Online Access:	https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1557560/full