Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer’s disease

Abstract Background Alzheimer’s disease is a neurodegenerative condition associated with the accumulation of two misfolded proteins, amyloid-beta (A $$\beta$$ β ) and tau. We study their effect on neuronal activity, with the aim of assessing their individual and combined impact. Methods We use a who...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Gustavo Patow, Leon Stefanovski, Petra Ritter, Gustavo Deco, Xenia Kobeleva, for the Alzheimer’s Disease Neuroimaging Initiative
Format:	Article
Language:	English
Published:	BMC 2023-12-01
Subjects:	Alzheimer’s disease Amyloid-beta Tau Whole-brain model Simulation
Online Access:	https://doi.org/10.1186/s13195-023-01349-9