Treating Cancer by Targeting Telomeres and Telomerase

Telomerase is expressed in more than 85% of cancer cells. Tumor cells with metastatic potential may have a high telomerase activity, allowing cells to escape from the inhibition of cell proliferation due to shortened telomeres. Human telomerase primarily consists of two main components: hTERT, a cat...

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Bibliographic Details
Published in:Antioxidants
Main Authors: Marko Ivancich, Zachary Schrank, Luke Wojdyla, Brandon Leviskas, Adijan Kuckovic, Ankita Sanjali, Neelu Puri
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Subjects:
telomerase
DNA damage responses
G-quadruplex
guanine-rich oligonucleotides (GROs)
telomere homolog oligonucleotides (T-oligos)
shelterin complex
Online Access:http://www.mdpi.com/2076-3921/6/1/15

Internet

http://www.mdpi.com/2076-3921/6/1/15

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