TG6002 oncolytic vaccinia virus and chemotherapy synergy: a promising strategy for pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant cancer characterized by poor prognosis and limited treatment options, often associated with significant toxicity. Recently, we described TG6002, an oncolytic vaccinia virus (VACV) engineered for tumor-selective replication through the del...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Johann Foloppe, Isabelle Farine, Christelle Pichon, Juliette Kempf, Julie Hortelano, Baptiste Moreau, Sandrine Cochin, Armelle Takeda, Patrick Pessaux, Philippe Erbs
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	pancreatic ductal adenocarcinoma oncolytic vaccinia virus TG6002 combination chemotherapy patient-derived tumor models
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1656984/full