Chronic fluoxetine modulates perineuronal nets and inhibitory neuronal function in relation to behavioral outcomes

Chronic fluoxetine administration has been reported to enhance neural plasticity in the adult brain, but the underlying structural correlates remain incompletely understood. In particular, the impact of fluoxetine on aggrecan-positive perineuronal nets (PNNs)—critical regulators of plasticity—is lar...

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Bibliographic Details

Published in:	IBRO Neuroscience Reports
Main Authors:	Hiroshi Ueno, Eriko Kitano, Sachiko Mori, Yu Takahashi, Shinji Murakami, Kenta Wani, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
Format:	Article
Language:	English
Published:	Elsevier 2025-12-01
Subjects:	Fluoxetine Neuroplasticity Perineuronal nets Aggrecan Parvalbumin Behavior
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667242125001654