Perturbation of Pseudomonas aeruginosa peptidoglycan recycling by anti-folates and design of a dual-action inhibitor

ABSTRACT Peptidoglycan (PG) is an important bacterial macromolecule that confers cell shape and structural integrity, and is a key antibiotic target. Its synthesis and turnover are carefully coordinated with other cellular processes and pathways. Despite established connections between the biosynthe...

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Bibliographic Details
Published in:mBio
Main Authors: Luke N. Yaeger, David Sychantha, Princeton Luong, Shahrokh Shekarriz, Océane Goncalves, Annamaria Dobrin, Michael R. Ranieri, Ryan P. Lamers, Hanjeong Harvey, George C. diCenzo, Michael Surette, Jean-Phiippe Côté, Jakob Magolan, Lori L. Burrows
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Subjects:
Pseudomonas aeruginosa
Escherichia coli
cell wall
antibiotic resistance
antibiotic combinations
folate
Online Access:https://journals.asm.org/doi/10.1128/mbio.02984-24

Internet

https://journals.asm.org/doi/10.1128/mbio.02984-24

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