Investigation of a combination therapy approach for the treatment of melioidosis

The efficacy of finafloxacin as a component of a layered defense treatment regimen was determined in vitro and in vivo against an infection with Burkholderia pseudomallei. Doxycycline was down-selected from a panel of antibiotics evaluated in vitro and used in combination with finafloxacin in a Balb...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Kay B. Barnes, Mark I. Richards, Gary Burgess, Stuart J. Armstrong, Christine Bentley, Thomas C. Maishman, Thomas R. Laws, Michelle Nelson, Sarah V. Harding
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	Burkholderia pseudomallei therapy melioidosis antibiotics mice
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.934312/full