Effect of glycosylation on the affinity of the MTB protein Ag85B for specific antibodies: towards the design of a dual-acting vaccine against tuberculosis

Abstract Background To create a dual-acting vaccine that can fight against tuberculosis, we combined antigenic arabino-mannan analogues with the Ag85B protein. To start the process, we studied the impact of modifying different parts of the Ag85B protein on its ability to be recognized by antibodies....

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Bibliographic Details

Published in:	Biology Direct
Main Authors:	Roberta Bernardini, Sara Tengattini, Zhihao Li, Luciano Piubelli, Teodora Bavaro, Anamaria Bianca Modolea, Maurizio Mattei, Paola Conti, Stefano Marini, Yongmin Zhang, Loredano Pollegioni, Caterina Temporini, Marco Terreni
Format:	Article
Language:	English
Published:	BMC 2024-01-01
Subjects:	Lipoarabinomannan Tuberculosis Mycobacterium Glycoconjugate Antibodies Vaccine
Online Access:	https://doi.org/10.1186/s13062-024-00454-5