TIGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre

Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses. Using severe COVID-19 as a paradigm of immune dysregulation, we have explored how cTfh phenotype relates to the titre and...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Natalie M. Edner, Luke P. Houghton, Elisavet Ntavli, Chloe Rees-Spear, Lina Petersone, Chunjing Wang, Astrid Fabri, Yassin Elfaki, Andrea Rueda Gonzalez, Rachel Brown, Kai Kisand, Pärt Peterson, Laura E. McCoy, Lucy S. K. Walker
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	follicular helper T cells antibody response TIGIT B cell help COVID-19
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1395684/full