Deficiency in MT5-MMP Supports Branching of Human iPSCs-Derived Neurons and Reduces Expression of GLAST/S100 in iPSCs-Derived Astrocytes

For some time, it has been accepted that the β-site APP cleaving enzyme 1 (BACE1) and the γ-secretase are two main players in the amyloidogenic processing of the β-amyloid precursor protein (APP). Recently, the membrane-type 5 matrix metalloproteinase (MT5-MMP/MMP-24), mainly expressed in the nervou...

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Bibliographic Details

Published in:	Cells
Main Authors:	Nikita Arnst, Pedro Belio-Mairal, Laura García-González, Laurie Arnaud, Louise Greetham, Emmanuel Nivet, Santiago Rivera, Alexander Dityatev
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Subjects:	Alzheimer’s disease human-induced pluripotent stem cells disease modeling neuronal differentiation hiPSC-derived astrocytes metalloproteinase
Online Access:	https://www.mdpi.com/2073-4409/10/7/1705