Localized sclerostin accumulation in osteocyte lacunar-canalicular system is associated with cortical bone microstructural alterations and bone fragility in db/db male mice

Bone fragility in type 2 diabetes mellitus (T2DM) is often characterized by impaired bone quality, despite normal or increased bone mineral density. Serum sclerostin levels are elevated in diabetes, yet its role in bone fragility is not fully understood. Sclerostin (SOST) is a Wnt signaling inhibito...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Xingfan Wu, Yuanli Ai, Yutao He, Dan Ma, Xi Li, Xiao Huang, Rui Cheng, Bin Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Subjects:	sclerostin lacunar-canalicular system diabetes bone fragility localized accumulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1562764/full