Ecofriendly synthesis of pyrimidine derivatives: exploring their anticoccidial efficacy and cytotoxic effect on WI-38 cells

Abstract A number of new heterocyclic compounds based on the pyrimidine moiety were created, with potential antiparasitic characteristics. The starting material, 4-(4-cyanophenyl)-6-oxo-2-thioxohexahydropyrimidine-5-carbonitrile (1), was synthesized using two methods: a conventional approach involvi...

Full description

Bibliographic Details

Published in:	Journal of Saudi Chemical Society
Main Authors:	Doaa A. Elsayed, Wesam S. Shehab, Mostafa I. Abdelglil, Hend A. Haikal, Mariusz Jaremko, Ahmed F. EL-Farargy, Sahar M. Mousa, Gehan T. El-Bassyouni, Samar M. Mouneir, Marwa M. Khalifa
Format:	Article
Language:	English
Published:	Springer 2025-08-01
Subjects:	Nanoparticles Pyrimidine derivatives Anticoccidial efficacy Cytotoxic effect WI-38 cells
Online Access:	https://doi.org/10.1007/s44442-025-00027-9