Ablating UNG activity in a mouse model inhibits colorectal cancer growth by increasing tumor immunogenicity

Uracil DNA glycosylase (UNG) excises uracil and 5-fluorouracil bases from DNA and is implicated in fluorodeoxyuridine (FdU) resistance. Here we explore the effects of inhibiting UNG activity, or depleting the UNG protein, in 2 mouse syngeneic models for colorectal cancer. Overexpressing the small UN...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Eric S. Christenson, Brandon E. Smith, Thanh J. Nguyen, Alens Valentin, Soren Charmsaz, Nicole E. Gross, Sarah M. Shin, Alexei Hernandez, Won Jin Ho, Srinivasan Yegnasubramanian, James T. Stivers
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2025-08-01
Subjects:	Genetics Immunology Oncology
Online Access:	https://doi.org/10.1172/jci.insight.184435