SGK1-inhibition restores cardiac repolarization in LQT2 rabbits and LQT3 mice by reducing late sodium current

Current management does not fully prevent arrhythmias in long QT syndrome (LQTS), underscoring a need for novel therapies. Here, we investigated potential beneficial effects of serum/glucocorticoid-regulated-kinase-1 (SGK1)-inhibition in different LQTS animal models. Ventricular cardiomyocytes (CMs)...

Full description

Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	Miriam Barbieri, Simona Casini, Julien Louradour, Tanja M. de Waal, Nicolò Alerni, Arie O. Verkerk, Federica Giannetti, Luca Sala, Philip T. Sager, Saumya Das, Gideon Koren, Manfred Zehender, Michael Brunner, Lior Gepstein, Lia Crotti, Peter J. Schwartz, Arthur A.M. Wilde, Katja E. Odening, Carol A. Remme
Format:	Article
Language:	English
Published:	Elsevier 2026-05-01
Subjects:	Long QT syndrome SGK1-inhibition Late sodium current Cardiac repolarization Antiarrhythmic mechanisms Transgenic animal models
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661826001040