Enhancer engagement sustains oncogenic transformation and progression of B-cell precursor acute lymphoblastic leukemia

Abstract Background Enhancer reprogramming plays a significant role in the heterogeneity of cancer. However, we have limited knowledge about the impact of chromatin remodeling in B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) patients, and how it affects tumorigenesis and drug response. Our...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Giacomo Corleone, Cristina Sorino, Matteo Caforio, Stefano Di Giovenale, Francesca De Nicola, Frauke Goeman, Valentina Bertaina, Angela Pitisci, Clelia Cortile, Franco Locatelli, Valentina Folgiero, Maurizio Fanciulli
Format:	Article
Language:	English
Published:	BMC 2024-06-01
Subjects:	Cis-regulatory elements BCP-ALL CRISPR/Cas-9 MYB DCTD
Online Access:	https://doi.org/10.1186/s13046-024-03075-y