Exploring Kv1.2 Channel Inactivation Through MD Simulations and Network Analysis

The KCNA2 gene encodes the Kv1.2 channel, a mammalian Shaker-like voltage-gated K+ channel, whose defections are linked to neuronal deficiency and childhood epilepsy. Despite the important role in the kinetic behavior of the channel, the inactivation remained hereby elusive. Here, we studied the Kv1...

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Flavio Costa, Carlo Guardiani, Alberto Giacomello
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-12-01
Subjects:	Shaker Kv1.2 C-type inactivation molecular dynamics network analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.784276/full