Soluble (Pro)Renin Receptor Levels Are Regulated by Plasma Renin Activity and Correlated with Edema in Mice and Humans with HFrEF

Symptomatic heart failure with reduced ejection fraction (HFrEF) is characterized by edema and chronic pathological activation of the classical renin–angiotensin–aldosterone system (RAAS). The soluble (pro)renin receptor (s(P)RR) is released into circulation by proteolytic cleavage of tissue express...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Inna P. Gladysheva, Ryan D. Sullivan, Kodangudi Ramanathan, Guy L. Reed
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Subjects:	soluble (pro)renin receptor renin plasma activity HFrEF edema
Online Access:	https://www.mdpi.com/2227-9059/10/8/1874