Reverse cholesterol transport: current assay methods, alterations with disease and response to therapeutic intervention

The removal of excess cholesterol from the body by High-density lipoprotein (HDL) in a process termed reverse cholesterol transport (RCT) has long been proposed to play a critical role in reduction of the lipid burden in arterial wall atherosclerotic lesions. While HDL-cholesterol levels are associa...

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Bibliographic Details

Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Martin P. Playford, Edward B. Neufeld, Rafael Zubirán, Alan T. Remaley
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	cholesterol ABCA1 ApoA-1 inflammation reverse cholesterol transport (RCT)
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2025.1608384/full