Archived Guthrie blood spots as a novel source for quantitative DNA methylation analysis

Sodium bisulfite treatment followed by PCR and DNA sequencing is widely considered the gold standard for the analysis of DNA methylation patterns. However, this technique generally requires substantial quantities of genomic DNA as starting material and is often associated with degradation of DNA. He...

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Bibliographic Details
Published in:BioTechniques
Main Authors: Nicholas C. Wong, Ruth Morley, Richard Saffery, Jeffrey M. Craig
Format: Article
Language:English
Published: Taylor & Francis Group 2008-10-01
Online Access:https://www.future-science.com/doi/10.2144/000112945