Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality

IntroductionRecent vaccine and infectious disease studies have highlighted the importance of antibodies that activate cellular Fc functions, including antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC), which are mediated by different Fc gamma Recepto...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Suzanne K. Shoffner-Beck, Robert M. Theisen, Kade E. Wong, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Stephen Kent, Amy W. Chung, Kelly B. Arnold
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	antibody-mediated effector functions antibody-dependent cellular cytotoxicity (ADCC) human immunodeficiency virus (HIV) ordinary differential equation model mechanistic model
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1578500/full